POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions.
Aging
Yu Y, Tan R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y, Lan L, Mao Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2017
Cell Counting & Viability
No items found.
Key Finding
In addition, the authors found that overexpression of POT1 inhibits the protein stability of Lig3, which is the major regulator of alternative NHEJ (alt-NHEJ), therefore suppressing the efficiency of alt-NHEJ.
Countstar Connection
The study's cell samples underwent cell-count assessment with a Countstar instrument during culture monitoring in the 2017 Aging study.
