Pirfenidone facilitates immune infiltration and enhances the antitumor efficacy of PD-L1 blockade in mice.
Oncoimmunology
Qin W, Zou J, Huang Y, Liu C, Kang Y, Han H, Tang Y, Li L, Liu B, Zhao W, Yuan X.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2020
Cancer Research
Immunology
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Key Finding
Co-administration of pirfenidone with PD-L1 blockades significantly delayed the tumor growth and increased survival, compared with the effect of either treatment alone. Combination therapy promoted gene expression with a unique signature associated with innate and adaptive immune response ed in the infiltration of immune cells and optimal T cell positioning.
Countstar Connection
The study obtained flow-cytometry measurements from the study's cell samples using Countstar (model not specified) during preparation for downstream cell analysis.
