Phylloquinone Attenuates Oxygen-Glucose Deprivation-induced Neuronal Injury by Inhibiting Ferroptosis via the xCT/GPX4 Pathway.
Neurochemical research
Xia Q, Li L, Li Y, Wang Z, He D, Liu Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cell Counting & Viability
No items found.
Key Finding
Mechanistic investigation revealed that Kruppel-like factor 2 (Klf2) is a potential target of phylloquinone and participates in its neuroprotective effects. These findings indicate that phylloquinone protects neurons from OGD-induced injury by inhibiting ferroptosis through the xCT/GPX4 pathway, highlighting its potential as a therapeutic candidate for ischemic neuronal damage.
Countstar Connection
The study's cell samples underwent cell-count and viability assessment with a Countstar instrument during cell-culture monitoring.
