PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow.
Nature communications
Yu Y, Wang RR, Miao NJ, Tang JJ, Zhang YW, Lu XR, Yan PY, Wang J, Jia XM.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2022
Immunology
Microbiology
No items found.
Key Finding
PD-L1 blockade or inhibition of PD-L1 expression increased neutrophil release from bone marrow and enhanced antifungal immunity. The study identified a Dectin-1/PD-L1 cascade through which beta-glucans restrain neutrophil mobilization, establishing PD-L1 as a negative regulator of antifungal innate immunity.
Countstar Connection
The study's cell samples underwent cell-count assessment with Countstar (model not specified) during migration assessment in the 2022 Nature communications study.
