SCIENTIFIC EVIDENCE

PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation.

Theranostics

Xu P, Jiang L, Yang Y, Wu M, Liu B, Shi Y, Shen Q, Jiang X, He Y, Cheng D, Xiong Q, Yang Z, Duan L, Lin J, Zhao S, Shi P, Yang C, Chen Y.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2020

Cancer Research

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Key Finding

The findings suggest that PAQR4 depletion enhances the sensitivity of cancerous cell to chemotherapy both in vitro and xenograft tumor formation in vivo, by promoting Nrf2 protein degradation through a Keap1-mediated ubiquitination process.

Countstar Connection

The study's cell samples underwent flow-cytometry cell assessment with a Countstar instrument during the study's growth assessment.

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