SCIENTIFIC EVIDENCE

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway.

International journal of molecular medicine
Rong Y, Yu H, Yin H, Li S, Wang J, Shen Z, Ding X, Bu F, Dai T, Wu G, Hua Z.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2026
Bioprocessing
Single-Cell Analysis
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Key Finding
These findings indicated that KDM6A catalyzed the removal of H3K27 methylation at the promoters of Wnt3a and RUNX2, thereby relieving their transcriptional repression. The KDM6A‑mediated oxygen response mechanism is a potential target for enhancing bone regeneration during fracture repair.
Countstar Connection
The research used Countstar Rigel S2 for cell-concentration and viability assessment in the study's cell samples before single-cell analysis for the reported research.
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