SCIENTIFIC EVIDENCE

Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.

Oncology reports
Lin JX, Xie XS, Weng XF, Qiu SL, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM, Zheng CH.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2019
Cancer Research
No items found.
Key Finding
Gastric cancer cell lines stably overexpressing IC53d were established to observe its effects on cell proliferation, invasion and migration, and on in vivo tumorigenicity, and the mechanism of action was explored. In addition, high cyclin D1 expression was associated with a significantly worse prognosis for patients compared with in patients with low cyclin D1 expression.
Countstar Connection
Countstar (model not specified) supported cell numbers measurement in cell suspensions during growth assessment for the cancer-model experiments.
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