SCIENTIFIC EVIDENCE

OT17 a novel microsatellite stable colorectal cancer cell line and organoid model for investigating BRAF V600E mutant tumorigenesis and targeted therapeutics.

Biochemistry and biophysics reports
Zheng C, Tang X, Wang S, Xu Y, Jia K, Gao G, Wei G, Niu G, Wu Y, Qian X, Zhu Y, Xiang D.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
3D Culture
Cancer Research
Organoid Culture
Single-Cell Analysis
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Key Finding
The OT17 cell line demonstrated robust tumorigenicity in vivo, achieving a 100 % success rate in forming subcutaneous tumors in NOD-scid Il2rg -/- (NSG)(NSG) mice. Additionally, a corresponding 3D organoid model (CO17) was established, which retained genetic concordance with OT17, further validating its relevance for preclinical applications.
Countstar Connection
Researchers relied on Countstar (model not specified) for cell-count measurements in cell suspensions during the study's growth assessment.
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