NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.
Genes & development
Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2015
Cell Counting & Viability
No items found.
Key Finding
Although mTORC1 activation by positive signals, such as growth factors and nutrients, has been extensively investigated, the mechanism of mTORC1 regulation by stress signals is less understood. The study reveals a function of NLK in stress-induced mTORC1 modulation and the underlying biochemical mechanism of NLK in mTORC1 inhibition in stress response.
Countstar Connection
The research obtained cell-count measurements from the study's cell samples using a Countstar instrument during growth assessment for the reported research.
