SCIENTIFIC EVIDENCE

Neuropilin-1-Mediated SARS-CoV-2 Infection in Bone Marrow-Derived Macrophages Inhibits Osteoclast Differentiation.

Advanced biology
Gao J, Mei H, Sun J, Li H, Huang Y, Tang Y, Duan L, Liu D, Pang Y, Wang Q, Gao Y, Song K, Zhao J, Zhang C, Liu J.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Immunology
Single-Cell Analysis
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Key Finding
Importantly, it is found that authentic SARS-CoV-2 infection impedes BMM-to-osteoclast differentiation. Collectively, this study provides evidence for NRP1-mediated SARS-CoV-2 infection in BMMs and establishes a potential link between disturbed osteoclast differentiation and disordered skeleton metabolism in COVID-19 patients.
Countstar Connection
Measurement of cell viability in the study's cell samples was performed with Countstar (model not specified) before single-cell analysis in the 2022 Advanced biology study.
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