SCIENTIFIC EVIDENCE

Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I.

Science advances

Nie H, Liu B, Yin C, Dong Z, Pan Y, Li P, Hu Q, Wang J, Tai Y, Shao X, Tian G, Wang C, Fang J, Liu B.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2025

Immunology

Single-Cell Analysis

Mira FL

Key Finding

Reg3beta was produced by dorsal root ganglion neurons after model establishment and promoted local infiltration of proinflammatory macrophages. A neuronal Reg3beta-macrophage TNF-alpha positive-feedback loop sustained dorsal root ganglion neuroinflammation and persistent pain in the rat CRPS-I model.

Countstar Connection

For the study's cell samples, Countstar Mira FL supplied cell-viability measurements during preparation for single-cell or single-nucleus analysis.

View paper ↗

Stay Connected to

Get new publications, application notes, cell analysis insights, and Countstar updates delivered to your inbox.

Meet us online