Neuroinvasive virus facilitates viral replication by employing lipid droplets to reduce arachidonic acid-induced ferroptosis.
The Journal of biological chemistry
Zhao J, Wang Q, Liu Z, Zhang M, Li J, Fu ZF, Zhao L, Zhou M.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2024
Microbiology
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Key Finding
The lipidomics analysis revealed that arachidonic acid (AA) was significantly increased after reducing LD formation by restricting diacylglycerol acyltransferase, and AA was further demonstrated to induce ferroptosis to inhibit neuroinvasive virus replication. Moreover, lipid peroxidation and viral replication inhibition could be significantly alleviated by a ferroptosis inhibitor, ferrostatin-1, indicating that AA affected neuroinvasive virus replication mainly through inducing ferroptosis.
Countstar Connection
Cell numbers were measured in the study's cell samples with Countstar (model not specified) during quality assessment in the 2024 The Journal of biological chemistry study.
