Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions.
Nature communications
Gu J, Lao L, Hu L, Zang J, Liu C, Wan R, Tang L, Yuan Y, Chen Y, Lin S.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cell Counting & Viability
No items found.
Key Finding
Dysregulation of the liver proteome under alcoholic conditions leads to alcohol-associated liver disease (ALD), a major health challenge worldwide. The authors discover that Phb1/2 is an important transcription coregulator in the process of ethanol metabolism, and one identified fatty acid metabolism enzyme Acsl1/5, whose inhibition protects cells and mice from lipid accumulation, a key symptom of hepatic steatosis.
Countstar Connection
Countstar (model not specified) was used to quantify cell numbers in the study's cell samples during sample-quality assessment.
