Nano-micrometer surface roughness gradients reveal topographical influences on differentiating responses of vascular cells on biodegradable magnesium.

Distinctively directing endothelial cells (ECs) and smooth muscle cells (SMCs), potentially by surface topography cue, is of central importance for enhancing bioefficacy of vascular implants. Further insights into the underlying regulatory mechanism are gained at subcellular and gene levels.

The researchers assessed cell numbers in the study's cell samples with a Countstar instrument during cell-culture monitoring.