Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model.
Bioresources and bioprocessing
Wang L, Wang X, Wang T, Zhuang Y, Wang G.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2021
Cancer Research
Immunology
Single-Cell Analysis
No items found.
Key Finding
Summarizing, this study formulates a rapid, scalable and reproducible in vitro model of 3D MTS for drug screening purposes, and the findings establish a critical role of glycolytic metabolism, ER hemostasis and ECM proteins expression profiling in tumor chemoresistance of HeLa carcinoma cells towards 5-FU.
Countstar Connection
Countstar (model not specified) was used to quantify cell numbers in the study's cell samples during preparation for single-cell or single-nucleus analysis.
