Multi-omics analysis and evidence of IL1R1 as a potential biomarker for diabetes-associated intervertebral disc degeneration.
Frontiers in immunology
Yi M, Lin W, Liu S, Zhang Y, Song J, Yin Y, Ding L.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Immunology
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Key Finding
IL1R1 was highly expressed in specific diabetes-associated NP subpopulations and showed significant positive correlation with neutrophil infiltration. Discussion These findings establish IL1R1 as a pivotal molecular bridge connecting T2DM and IDD, driven by neutrophil-mediated inflammation and NP cell dysfunction, offering novel diagnostic and therapeutic avenues.
Countstar Connection
The research obtained cell-concentration and viability measurements from the study's cell samples using Countstar (model not specified) before single-cell analysis for the reported research.
