SCIENTIFIC EVIDENCE

Multi-modal characterization of metabolic and immune gene clusters in adrenocortical carcinoma treatment.

NPJ precision oncology

Hao W, Yao L, Wang Y, Wan J, Zhu Y, Dai Z, Sun X, Fan B, Wang Y, Xiang H, Gao X, Liang P, Zhao H, Wang L, Wang Y, Wang H, Yang D, Liu Z.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2025

Cancer Research

Immunology

Single-Cell Analysis

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Key Finding

Single-cell RNA sequencing data revealed the relationship between the tumor microenvironment and drug resistance in ACC. In vitro functional assays demonstrated that elevated DHCR7 gene expression correlated with unfavorable prognosis and treatment sensitivity, identifying it as a prospective therapeutic target.

Countstar Connection

Single-cell suspensions underwent cell-concentration and viability assessment with Countstar (model not specified) before single-cell analysis for the cancer-model experiments.

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