SCIENTIFIC EVIDENCE

MTCH2 Deficiency Promotes E2F4/TFRC-Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Xing P, Chen J, Hao H, Qiao X, Yang X, Weng K, Chen J, Song L, Liu T, Hou Y, Song T, Ran Y, Chen B, Yang H, Zhao W, Wang Z, Di J, Jiang B, Su X.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2025

Cancer Research

Single-Cell Analysis

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Key Finding

Taken together, This study reveals the mechanism of MTCH2 deficiency-induced ferroptosis to inhibit the progression of CRC and supports a potential therapeutic strategy targeting the MTCH2/E2F4/TFRC signaling axis in CRC patients with liver metastasis.

Countstar Connection

The researchers relied on Countstar (model not specified) to measure cell viability in the study's cell samples before single-cell analysis for the cancer-model experiments.

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