SCIENTIFIC EVIDENCE

MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling.

Signal transduction and targeted therapy
Shen Q, Han Y, Wu K, He Y, Jiang X, Liu P, Xia C, Xiong Q, Liu R, Chen Q, Zhang Y, Zhao S, Yang C, Chen Y.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Cancer Research
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Key Finding
On the contrary, MrgprF knockdown promotes tumor cell proliferation and transformation of immortalized human keratinocyte-HaCaT cells, supporting the inhibitory role of MrgprF during tumor progression. Taken together, the findings suggest that MrgprF, a novel tumor suppressor in cutaneous melanoma, may be useful as a therapeutic target in the future.
Countstar Connection
Countstar (model not specified) quantified flow-cytometry cell measurements in tumor-cell samples during growth assessment in the 2022 Signal transduction and targeted therapy study.
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