Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells.
Oncotarget
Meng G, Xia M, Wang D, Chen A, Wang Y, Wang H, Yu D, Wei J.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2014
Cancer Research
Microbiology
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Key Finding
Moreover, the authors found that NDV recruited SQSTM1-mediated mitophagy to control cytochrome c release, and thus blocked intrinsic pro-apoptotic signaling. Finally, the authors observed an enhanced oncolysis in NSCLC cells treated with NDV in the presence of an autophagy inhibitor 3-methyladenine (3-MA).
Countstar Connection
Countstar (model not specified) measured cell numbers in the study's cell samples during quality assessment in the 2014 Oncotarget study.
