Mitochondrial pyruvate metabolism in club cells drives airway inflammation.
Stem cell reports
Wang J, Du C, Hao, Wu Q, Gui B, Li Y, Li K, Li X, Zhang Q, Li L, Chen H.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Bioprocessing
Single-Cell Analysis
No items found.
Key Finding
Mpc2 loss increased Cxcl17 expression in club cells, promoting Cxcl17-Cxcr4 signaling with alveolar macrophages that suppressed CCL17-mediated type 2 inflammation. These findings reveal a metabolic-immune crosstalk underlying asthma pathogenesis and identify mitochondrial pyruvate metabolism as a therapeutic target to limit epithelial remodeling and type 2 inflammation.
Countstar Connection
The study obtained cell-concentration and viability measurements from single-cell suspensions with Countstar (model not specified) before single-cell analysis in the 2026 Stem cell reports study.
