Mpc2 loss increased Cxcl17 expression in club cells, promoting Cxcl17-Cxcr4 signaling with alveolar macrophages that suppressed CCL17-mediated type 2 inflammation. These findings reveal a metabolic-immune crosstalk underlying asthma pathogenesis and identify mitochondrial pyruvate metabolism as a therapeutic target to limit epithelial remodeling and type 2 inflammation.
Countstar Connection
The study obtained cell-concentration and viability measurements from single-cell suspensions with Countstar (model not specified) before single-cell analysis in the 2026 Stem cell reports study.
