SCIENTIFIC EVIDENCE

Metabolism archetype cancer cells induce protumor TREM2 + macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma.

Nature communications
Chu T, Zhu G, Tang Z, Qu W, Yang R, Pan H, Wang Y, Tian R, Chen L, Guan Z, Bu Y, Zhao Q, Chen J, Mao S, Fang Y, Gao J, Wu X, Zhou J, Liu W, Ye D, Fan J, Shi Y.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
Immunology
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Key Finding
Further analysis shows an immune-suppressive niche populated by metabolism archetype cancer cells and TREM2-positive tumor-associated macrophages (TREM2 + TAMs), which exacerbates immune exclusion and compromises patient outcomes. Importantly, cancer cell-intrinsic SQLE and TREM2 + TAMs are associated with inferior immunotherapy response in human and mouse HCC.
Countstar Connection
The research used Countstar (model not specified) for cell-viability assessment in the study samples before single-cell analysis for the cancer-model experiments.
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