SCIENTIFIC EVIDENCE

MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB.

Signal transduction and targeted therapy
Wang X, Tao X, Chen P, Jiang P, Li W, Chang H, Wei C, Lai X, Zhang H, Pan Y, Ding L, Liang Z, Cui J, Shao M, Teng X, Gu T, Wei J, Kong D, Si X, Han Y, Fu H, Lin Y, Yu J, Li X, Wang D, Hu Y, Qian P, Huang H.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2024
Immunology
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Key Finding
The findings revealed that MEKIs attenuated CAR-T cell exhaustion and terminal differentiation induced by tonic signaling and antigen stimulation, thereby improving CAR-T cell efficacy against hematological and solid tumors. These mechanistic insights significantly broaden the potential application of MEKIs to enhance the effectiveness of CAR-T therapy.
Countstar Connection
Countstar (model not specified) was used to quantify flow-cytometry cell measurements in CAR-T-cell samples during sample-quality assessment.
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