SCIENTIFIC EVIDENCE

Mechanotransduction Mediated by PDLIM5: The Critical Role of Serpin E2/Integrin β3-Cytoskeleton-Nucleoskeleton Axis in Mechanical Osteogenic Programming.

Cell proliferation
Yang Y, Wu S, Wang Y, Tang J, Liu J, Wang J, Li Y, Khan AU, Khan MA, Liu W, Zhu J, Hu K, Dai J, Ouyang J.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
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Key Finding
Utilising proteomics and single-cell RNA sequencing, the authors identified PDLIM5 and serpin E2 as key genes associated with the osteogenic differentiation of stem cells. The findings indicate that PDLIM5 modulates the osteogenic differentiation of hASCs via a signalling pathway involving serpin E2, integrin β3 and lamin A.
Countstar Connection
A Countstar instrument generated cell-concentration measurements for the study's cell samples before single-cell analysis for the reported research.
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