Mechanical confinement promotes heat resistance of hepatocellular carcinoma via SP1/IL4I1/AHR axis.
Cell reports. Medicine
Zhang GP, Xie ZL, Jiang J, Zhao YT, Lei K, Lin ZL, Chen SL, Su TH, Tan L, Peng S, Wang J, Liu C, Kuang M.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2023
Cancer Research
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Key Finding
Mechanistically, the activation of transcription factor SP1 under mechanical confinement enhances the transcription of Interleukin-4-Induced-1, which catalyzes tryptophan metabolites to activate the aryl hydrocarbon receptor (AHR), leading to heat resistance. These findings reveal a newly identified role of mechanical confinement in heat resistance and provide a rationale for AHR inhibitors as neoadjuvant therapy.
Countstar Connection
For the study's cell samples, Countstar (model not specified) provided cell-count measurements during quality assessment in the 2023 Cell reports. Medicine study.
