Functional experiments demonstrated the activation of fibroblasts in fibrotic ECM, which was alleviated by GPNMB-neutralizing antibodies or macrophage deletion in the ECM of silica-instilled mice. Moreover, the Serpinb2 expression level was increased in fibroblasts in fibrotic ECM, and the expression of CD44 was increased in silica-instilled mice.
Countstar Connection
The study used Countstar (model not specified) for cell assessment in the study's cell samples before single-cell analysis in the 2023 Communications biology study.
