SCIENTIFIC EVIDENCE

m 6 A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration.

Signal transduction and targeted therapy
Liu Y, Song R, Zhao L, Lu Z, Li Y, Zhan X, Lu F, Yang J, Niu Y, Cao X.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Immunology
Microbiology
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Key Finding
The findings reveal a newly identified role of ALKBH5 in imprinting migration-promoting transcriptome signatures in neutrophils and intrinsically promoting neutrophil migration for antibacterial defense, highlighting the potential application of targeting neutrophil m 6 A modification in controlling bacterial infections.
Countstar Connection
Countstar (model not specified) supplied migrated- or invaded-cell counts for the study's cell samples during migration assessment in the 2022 Signal transduction and targeted therapy study.
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