Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs.
Nature communications
Zheng Y, Cong L, Zhao L, Wang P, Xing L, Liu J, Xu H, Li N, Zhao Y, Yuan L, Shi Q, Sun X, Liang Q, Wang Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Stem Cell Research
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Key Finding
Moreover, unblocked lymphatic drainage decreases neutrophils and increases M2-type macrophages of the hematoma niche to support osteoblast (OB) survival and bone marrow-derived mesenchymal stem cell (BMSC) proliferation via transporting damage-associated molecular patterns (DAMPs) in male rats. These findings demonstrate that LPT limits bone regeneration by impeding lymphatic transporting DAMPs.
Countstar Connection
Countstar (model not specified) measured cell numbers in cell suspensions during quality assessment for the reported research.
