Long-Term High-Fat Diet Affected Bone Marrow Microenvironment During Aging at Single-Cell Resolution.
MedComm
Pang Y, Zhu S, Ding P, Zhang S, Zhang Y, Ye F, Zhang C, Gao J, Yin J.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
No items found.
Key Finding
The findings demonstrate that bone marrow macrophages of the LHA group upregulated Chil3 and Fabp4, which are associated with inflammatory response and regulation of adipocytes. The findings indicated the bone marrow microenvironment as a central hub of LHA-induced pathology, where adipogenic reprogramming and myeloid cell dysfunction collectively drive skeletal and systematic inflammation.
Countstar Connection
Countstar (model not specified) served as the instrument for cell-viability assessment in the study's cell samples before single-cell analysis in the 2025 MedComm study.
