SCIENTIFIC EVIDENCE

Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein-1-H3K4me3-mediated immune escape in oesophageal squamous cell carcinoma.

Clinical and translational medicine
Liu J, Zhou WY, Luo XJ, Chen YX, Wong CW, Liu ZX, Bo Zheng J, Yu Mo H, Chen JQ, Li JJ, Zhong M, Xu YH, Zhang QH, Pu HY, Wu QN, Jin Y, Wang ZX, Xu RH, Luo HY.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2023
Cancer Research
Immunology
Single-Cell Analysis
No items found.
Key Finding
High LINC02096 (RIME) expression in plasma exosomes correlates with a reduced response to PD-1 mAb treatment and poor prognosis. RIME depletion in huPBMC-NOG mice significantly represses tumour development and improves the effectiveness of PD-1 mAb treatment by activating T-cell-mediated antitumour immunity.
Countstar Connection
Using Countstar Rigel S3, the study assessed cell concentration and viability in cell suspensions before single-cell analysis in the 2023 Clinical and translational medicine study.
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