LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.
Molecular cancer
He Y, Jiang X, Duan L, Xiong Q, Yuan Y, Liu P, Jiang L, Shen Q, Zhao S, Yang C, Chen Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2021
Cancer Research
Stem Cell Research
No items found.
Key Finding
The authors show that PKMYT1AR high expression correlates with worse clinical outcome, and knockdown of PKMYT1AR inhibits tumor cell proliferation, migration and xenograft tumor formation abilities. The findings reveal the critical role of PKMYT1AR/miR-485-5p /PKMYT1 axis during NSCLC progression, which could be used as novel therapeutic targets in the future.
Countstar Connection
A Countstar instrument measured cell numbers during growth assessment in the study's cell samples during the study's growth assessment.
