SCIENTIFIC EVIDENCE

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.

Nature

Qu Q, Chen Y, Wang Y, Wang W, Long S, Yang HY, Wu J, Li M, Tian X, Wei X, Liu YH, Xu S, Xiong J, Yang C, Wu Z, Huang X, Xie C, Wu Y, Xu Z, Zhang C, Zhang B, Feng JW, Chen J, Feng Y, Fang H, Lin L, Xie ZK, Sun B, Tian H, Yu Y, Piao HL, Xie XS, Deng X, Zhang CS, Lin SC.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2025

Bioprocessing

No items found.

Key Finding

Here the authors show that LCA enhances the activity of sirtuins to deacetylate and subsequently inhibit vacuolar H + -ATPase (v-ATPase), which leads to AMPK activation through the lysosomal glucose-sensing pathway. The study demonstrates that activation of the TULP3-sirtuin-v-ATPase-AMPK pathway by LCA reproduces the benefits of calorie restriction.

Countstar Connection

Within the research, a Countstar instrument assessed cell density in the study's cell samples during culture monitoring in the 2025 Nature study.

View paper ↗

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