Lipidomic analysis further revealed that HILPDA knockdown significantly decreased the levels of polyunsaturated fatty acid-phosphatidylcholines (PUFA-PCs) and phosphatidylethanolamines (PEs) under hypoxia. These findings identified the HIF-1α/2α-HILPDA-LPCAT3 axis as a pivotal pathway driving hypoxia-induced ferroptosis, therefore providing potential therapeutic targets for gastric and small intestinal mucosal injury associated with hypoxia.
Countstar Connection
Countstar Mira BF supported assessment of cell numbers in the study's cell samples during quality assessment in the 2026 PloS one study.
