SCIENTIFIC EVIDENCE

Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression.

Theranostics
Liu C, Jiang K, Ding Y, Yang A, Cai R, Bai P, Xiong M, Fu C, Quan M, Xiong Z, Deng Y, Tian R, Wu C, Sun Y.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2023
Cancer Research
Immunology
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Key Finding
Identifying key signaling pathways driving PDAC progression is crucial for the development of therapies to improve patient response rates. The study reveal a novel Kindlin-2-DDX3X-c-Myc signaling axis in PDAC progression and suggest that inhibition of this signaling axis may provide a promising therapeutic approach to alleviate PDAC progression.
Countstar Connection
The study obtained cell-count measurements from the study's cell samples using Countstar (model not specified) during the study's growth assessment.
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