SCIENTIFIC EVIDENCE

iPSC-derived ITGA6-positive cells restore aqueous humor outflow in glaucoma eyes.

Nature communications
Feng P, Yu C, Zhang X, Xu B, Wu S, Xin C, Littleton S, Kang J, Wang X, Liang S, Chen S, Wang W, Wang Y, Yuan Z, Xi G, Xing X, Ge X, Chang Z, Tan J, Zhang J, Zhang B, Cao Q, Xu W, Kuehn MH, Wang N, Zhu W.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
Stem Cell Research
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Key Finding
Decreased trabecular meshwork (TM) cellularity is a critical pathogenic cause of primary open-angle glaucoma, yet therapies to regenerate the decellularized TM are very limited. Enhancing paraspeckle assembly by MEN β-associated RNA promotes the rejuvenation and proliferation of pTM, suggesting a novel and promising approach for TM regeneration.
Countstar Connection
For cell suspensions, Countstar (model not specified) provided cell measurements before single-cell analysis in the 2025 Nature communications study.
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