Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.

This study provides mechanistic evidence that IFN-α stimulates DHX58 to promote the translation of m 6 A-modified Gpx4 mRNA, suggesting the potential clinical application of IFN-α in the prevention of hepatic ferroptosis during liver I/R injury.

The researchers relied on Countstar (model not specified) to measure cell viability in the study's cell samples before single-cell analysis for the reported research.