Integrative single-cell RNA-seq and ATAC-seq analysis of myogenic differentiation in pig.
BMC biology
Cai S, Hu B, Wang X, Liu T, Lin Z, Tong X, Xu R, Chen M, Duo T, Zhu Q, Liang Z, Li E, Chen Y, Li J, Liu X, Mo D.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2023
Single-Cell Analysis
No items found.
Key Finding
Some novel genes upregulated along the differentiation trajectory showed higher expression levels in muscular dystrophy mice than that in healthy mice, suggesting their involvement in myogenesis. Integrative analysis of chromatin accessibility, gene expression data, and in vitro experiments identified EGR1 and RHOB as critical regulators of pig embryonic myogenesis.
Countstar Connection
Within the study, Countstar (model not specified) measured cell number and viability in the study's cell samples during preparation for single-cell or single-nucleus analysis.
