Integrative profiling of untreated primary membranous nephropathy at the single-cell transcriptome level.
Clinical kidney journal
Gu Q, Wen Y, Cheng X, Qi Y, Cao X, Gao X, Mao X, Shang W, Wei L, Jia J, Yan T, Cai Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2024
Immunology
Single-Cell Analysis
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Key Finding
Accordingly, scRNA-seq analysis of urinary samples is partially reminiscent of the kidney cell landscape, especially T cells and myeloid cells, suggesting monitoring urinary samples is a promising to monitor PMN development. Finally, immune repertoire in PBMC also showed an elevated diversity of clonal type, implying the existence of autoreactive T-cell receptor/B-cell receptor.
Countstar Connection
Countstar Rigel S2 provided the instrument readout for cell number and viability in the study's cell samples before single-cell analysis for the study's single-cell analysis.
