Integration of exonuclease III-powered three-dimensional DNA walker with single-molecule detection for multiple initiator caspases assay.
Chemical science
Liu M, Xu R, Liu W, Qiu JG, Wang Y, Ma F, Zhang CY.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2021
Immunology
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Key Finding
The simultaneous detection of multiple initiator caspases is essential for apoptosis mechanism studies and disease therapy. Notably, the introduction of the AuNP-based 3D DNA walker greatly reduces the signal and amplifies the output signals, and the introduction of single-molecule detection further improves the detection sensitivity.
Countstar Connection
The study's cell samples underwent cell-count assessment with a Countstar instrument during growth assessment for the reported research.
