SCIENTIFIC EVIDENCE

Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu B, Xian Y, Chen X, Shi Y, Dong J, Yang L, An X, Shen T, Wu W, Ma Y, He Y, Gong W, Peng R, Lin J, Liu N, Guo B, Jiang Q.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2024

Immunology

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Key Finding

In addition, it is demonstrated that inf-exo stimulation triggers the activation of glycolysis. The provide novel insights into the involvement of FLS-derived exosomes in OA pathogenesis, suggesting that inf-exo-induced macrophage dysfunction represents an attractive target for OA therapy.

Countstar Connection

Cell-count assessment in the study's cell samples used a Countstar instrument during quality assessment for the immune-cell research.

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