IGF2BP3 enhances ferroptosis resistance in colon cancer by stabilizing SLC7A11 and is regulated by miR-98-5p.
Frontiers in oncology
Sun Y, Liu Q, Wu J, Jiang G, Shi H, Zhang Y, Ling Y, Sun W, Shi X, Liu C.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
No items found.
Key Finding
IGF2BP3 was significantly upregulated in colon cancer tissues and correlated with advanced T-stage, higher clinical stage, and poor survival (p IGF2BP3 drives ferroptosis resistance in colon cancer by stabilizing SLC7A11 mRNA, while miR-98-5p antagonizes this pathway via IGF2BP3 downregulation. Targeting the miR-98-5p/IGF2BP3/SLC7A11 axis offers a promising therapeutic strategy to enhance ferroptosis sensitivity and improve colon cancer outcomes.
Countstar Connection
Researchers relied on Countstar (model not specified) for cell-count measurements in cell suspensions during sample-quality assessment.
