IFN-I-mediated neutropoiesis bias drives neutrophil priming and inflammatory comorbidities.
Theranostics
Li Y, Chen Y, Deng C, Niu Y, Yang Y, Sun S, Hu Z, Wei Y, Xu M, Huang Y, Van Dyke T, Deng X.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Immunology
Single-Cell Analysis
No items found.
Key Finding
Rationale: Local chronic inflammation is increasingly recognized as a driver of systemic inflammatory comorbidities; however, the underlying mechanisms remain incompletely understood. Transcriptional and chromatin accessibility profiling demonstrated that LIP induces a selective skewing of HSPC differentiation toward the neutrophil lineage.
Countstar Connection
Countstar (model not specified) was the instrument used to assess cell number and viability in the study's cell samples during preparation for single-cell or single-nucleus analysis.
