IER3 Promotes Malignant Progression of Colorectal Cancer Through the NF- κ B Pathway.
International journal of genomics
Wei Z, Luo Y, Zhang Y, Huang Q, Shao J, Zhang Y, Zhang Y, Wang Z, Liang C, Lai Z, Cui Y, Zhang P.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Cancer Research
Immunology
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Key Finding
Mechanistically, IER3 activates the TNF- α /NF- κ B signaling pathway, thereby enhancing the expression and phosphorylation of RELA/p65. High IER3 expression correlates with reduced response to immune checkpoint blockade (ICB) and distinct drug sensitivity profiles.
Countstar Connection
Researchers relied on Countstar (model not specified) for cell-viability measurements in the study's cell samples during preparation for single-cell or single-nucleus analysis.
