Hypoxia-regulated lncRNA CRPAT4 promotes cell migration via regulating AVL9 in clear cell renal cell carcinomas.
OncoTargets and therapy
Zhang W, Wang J, Chai R, Zhong G, Zhang C, Cao W, Yan L, Zhang X, Xu Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2018
Cancer Research
No items found.
Key Finding
Kaplan-Meier survival analysis with The Cancer Genome Atlas KIRC RNA sequencing data indicated that high CRPAT4 expression was significantly associated with poor overall survival and progression-free survival. Functional studies indicated that CRPAT4 was an HIF-1α regulated gene, and CRPAT4 knockdown significantly inhibited cell migration and proliferation in the absence of HIF-1α.
Countstar Connection
The researchers assessed cell numbers in the study's cell samples with a Countstar instrument during the study's migration assessment.
