SCIENTIFIC EVIDENCE

Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury.

Scientific reports
Zhang L, Yang S, Cui H, Hang C, Wang X, An L, Shan Z, Liang Z, Shao R, Tang Z.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Cell Counting & Viability
No items found.
Key Finding
The showed that hypothermia alleviated MMP damage, inhibited mPTP opening, then decreased cell apoptosis and activated mitophagy at 2 h after temperature intervention, which might be mediated by the PINK1/Parkin-VDAC3 signaling pathway. Moreover, the effects of hypothermia were reduced or reversed at 4 h after temperature intervention.
Countstar Connection
Countstar (model not specified) supported measurement of cell numbers in the study samples during sample-quality assessment.
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