Humanized mouse model reveals T cell ANXA2 as a potential therapeutic target in ischemic stroke.
iScience
Zhang T, Zheng X, Lu A, Li S, Li K, Huang X, Liu Y, Chen W, Huang S, He N, Tsang CK, Mai H, Xu A, Lu D.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Immunology
Single-Cell Analysis
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Key Finding
Thus, this study established a humanized mouse model after middle cerebral artery occlusion (MCAO) and identifies potential therapeutic targets of humanized T cell populations. Similar to patients with stroke, a proportion of T cells was decreased in peripheral blood of humanized T cell stroke mice.
Countstar Connection
The researchers assessed cell number and viability in the study's cell samples with Countstar (model not specified) during preparation for single-cell or single-nucleus analysis.
