HUCMSC-derived Exosomes Suppress the Titanium Particles-induced Osteolysis in Mice through Inhibiting CCL2 and CCL3.
Orthopaedic surgery
Li S, Wu C, Lin S, Wen Z, Luo W, Li C, Wang X, Li X, Gao L, Ding Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2023
Immunology
No items found.
Key Finding
An exosome inhibitor GW4869 significantly increased the osteolysis area in the mice cranium osteolysis model, and increased the number of migrated macrophages. Immunohistochemical suggested that the expression of CCL2, CCL3 and CD68 in the cranial in Titanium particles mice increased significantly, but was significantly reduced by HUCMSCs or exosomes.
Countstar Connection
For the study's cell samples, Countstar (model not specified) supplied cell-count and viability measurements during cell-culture monitoring.
