SCIENTIFIC EVIDENCE

HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs.

Cell reports
Gaurav N, Qin W, Selvam K, Zhou Z, Liu J, Yin Y, Singh RK, O'Hara RA, Tavaf Z, Kumar A, Kono H, Narlikar GJ, Banaszynski LA, Leonhardt H, Kutateladze TG.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2026
Immunology
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Key Finding
In vivo rescue experiments using KAP1- and HP1-knockout mouse embryonic stem cells reveal a unique cooperative action of KAP1 and HP1γ, but not other HP1s, in the repression of the long noncoding RNA AI662270, underscoring the notion that cellular functions of HP1 proteins are not redundant.
Countstar Connection
Cell-count assessment in the study's cell samples was performed with Countstar (model not specified) during the study's growth assessment.
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