HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner.
Journal of molecular cell biology
Zhang R, Cui D, Xue T, Lang Y, Zhang Y, Li L, Sun H, Kuang Y, Li G, Tang J.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2020
Cell Counting & Viability
No items found.
Key Finding
Overexpression of Bat3 and HAUSP increases Mdm2 protein levels without influencing the p53-Mdm2 interaction and Mdm2-mediated p53 ubiquitination, indicating that Bat3-HAUSP-mediated protein stabilization is not specific to p53 and different mechanisms may be involved in Bat3-mediated regulation of p53-Mdm2 pathway.
Countstar Connection
Using Countstar (model not specified), the study measured cell numbers in the study's cell samples during the study's growth assessment.
