SCIENTIFIC EVIDENCE

Histone lactylation-induced premature senescence contributes to 1-nitropyrene-Induced chronic obstructive pulmonary disease.

Redox biology
Wang RR, Chen DL, Wei M, Li SR, Zhou P, Sun J, He QY, Yang J, Zhao H, Fu L.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Cell Counting & Viability
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Key Finding
CUT&Tag and ChIP-qPCR experiments confirmed that increased H3K14la directly upregulated p53 transcription in pulmonary epithelial cells. These data revealed for the first time that histone lactylation-induced the increase in p53 transcription contributes to pulmonary epithelial cell senescence during 1-NP-induced COPD progression.
Countstar Connection
The study used Countstar Rigel S2 for cell-count assessment in the study's cell samples during sample-quality assessment.
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